Methylenetetrahydrofolate reductase (MTHFR)

Lovenox

If you have ever taken Lovenox then you understand what i am about to say: my belly is on FIRE! That shot burns going in anc for a good 30 minutes after. My belly is bruised and miniature knots dot the surface. Thankfully Sunday is my last shot, regardless of how bloodwork comes back. For that i am thankful!

With that I wish everybody a happy and healthy holiday. I will be taking a break from blogging until after the holidays.

-R

Categories: Frozen Embryo Transfer, lovenox, Lupus Anti Coagulant, Methylenetetrahydrofolate reductase (MTHFR) | 2 Comments

Regrouping

The past two weeks have felt like four.  It’s hard to move forward when you don’t have any answers, and the one thing that I prayed would happen eluded me again.

Today was our meeting with the RE regarding our failed IVF and next steps, and hopefully some answers to a few questions.  I had no idea what to expect.

Our RE came in and reviewed our files with us and explained his thoughts on our cycle, concerns, and what is necessary for our next step.  Overall, the RE felt optimistic about our odds feels confident that our biological family is waiting in the cryo tanks.  But in order to get our baby, there are a few more hurdles to overcome.

1.  Improve Quality of Uterus Lining – Although my lining measured at 15.6 at the time of transfer previous tests could possibly point to cause for concern.  So today we started towards our first hurdle by having an ultrasound and reviewing photos taken in May of my uterus.  There was a note of a ridge or pocket in my uterus in May but the RE who did the procedure did not seem concerned.  Today the RE suggested we perform a curettage.  This is a scrapping of the lining in hopes of removing the ridge/pocket and allowing a new stronger, lining to build.  The curettage is scheduled for 10/10/12.  I will then be on estrogen for 21 days to help rebuild a strong, healthy lining.

2. Lupus Anticoagulant Returns – Although the hematologist felt that the Lupus Anticoagulant was not a concern, our RE feels that it very well could still be an issue.  As I posted before, lupus anticoagulant can be difficult to diagnose as its markers in your blood can come and go.  So, we will move forward as if I have lupus anticoagulant and go on Lovenox the day after transfer through 2nd rise in HCG.

3.  Prednisone – This is a corticosteroid and is used in IVF or FETs to help my body accept the embryos.

4. FET – After the curettage and building of my lining we will move forward with a frozen embryo transfer.  My body will be in a better place with no OHSS or the stress from the IVF, my lining will be strong and healthy, and the new protocol of medications will help increase our chances.  We will be able to transfer two embryos close to Christmas.

So, although today (not to mention the past month) was emotional we have regrouped and now have a few potential answers and a plan to help increase our chances.

-R

Categories: Frozen Embryo Transfer, Infertility, Infertility Testing, IVF, Lupus Anti Coagulant, Methylenetetrahydrofolate reductase (MTHFR) | 2 Comments

Hematology

This morning I woke up to unsettled nerves.  Today I met with the hematologist to discuss my MTHFR and Lupus Anticoagulant and I was uncertain how this news would impact my life or the upcoming IVF protocol.  The appointment was confusing, provided a little relief, added a cause for fear of something I never imagined, and still I left with a few questions unanswered.

What I learned. The Lupus Anticoagulant syndrome is one of the most confusing blood disorders one can have.  The clotting antibodies that are present in those with Lupus Anticoagulant can come and go (show up for months and then not be present for some time before showing up again), individuals who have it can go years without any issues, is something that “just happens” and is not a genetic issue, the antibodies can be present in individuals who do NOT have the disorder (in almost 5% of the general population),  and it was first discovered in persons with Lupus (the autoimmune disease).   I also learned that it is not necessarily something that would require daily anticoagulants for the rest of my life.  Really, only for high risk situations like surgery, broken legs, pregnancy, and birth.

Although my original test came out positive for LA, it may not be conclusive and more blood was provided.  The hematologist feels I have some factors that point to LA but others that do not.  Further testing was needed and within a week I will know for certain if I do indeed have Lupus Anticoagulant.  Regardless of how the tests come back the hematologist wants me on Lovenox from at least the day of transfer through the first beta test (pregnancy hormone test).  He discussed that it is likely that he’ll want me on Lovenox through the last month of pregnancy, switching to a different anticoagulant 2 weeks prior to due date, and then for 6 weeks after delivery.

Here is where the fear comes in.  The 6 weeks after delivery hold the greatest risk for things like blood clots in legs and pulmonary embolism.  Women naturally develop increased clotting antibodies as their pregnancy develops.  If they didn’t women would die from blood loss during delivery.  So, a person who already has high clotting antibodies acquires more chance for dangerous clots to occur.  Blah!  Nothing is easy!

I feel like I’m rambling so I will call this post complete.

-R

Categories: Infertility, IVF, Lupus Anti Coagulant, Methylenetetrahydrofolate reductase (MTHFR) | Tags: , , , | Leave a comment

Yet Another Shove

Today brought a variety of emotion.  Relief to begin acupuncture, and with that some much-needed relaxation after a day of not so happy news.  Yet another shove to my dreams.  My lab work from the 11th came back and I had two abnormalities:

Methylenetetrahydrofolate reductase (MTHFR) – A mutation in the methylenatetrahydofolate gene that prohibits my body from absorbing folic acid (among other things) and can lead to complications during pregnancy (placenta disease, preeclampsia, recurrent miscarriage, and chromosomal abnormalities) .

Lupus Anti Coagulant – Basically a blood disorder that causes blood in your veins to clot and lead to things like pulmonary embolism, stroke, heart attacks, and blood clots in arms/legs.  It also causes recurrent miscarriage and problems with implantation.

That’s it…two more hurdles to overcome.  I have to make an appointment with the hematologist this week so that I can put a game plan together, not only for the IVF cycle, but for my general health.  The only silver lining that I can see is that I am finally at a clinic that is thorough and honest.  This may have never been found at my previous clinic.  For that I am grateful.

-R

Categories: Infertility, Infertility Testing, Lupus Anti Coagulant, Methylenetetrahydrofolate reductase (MTHFR) | Tags: , | 2 Comments

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